Commonly, SSRIs are used to treat.
Moms-to-Be
CHARLOTTESVILLE, Va., Dec. 19,
2022 – Antidepressant use during pregnancy when combined
Inflammation may increase the chance of a lifelong illness.
neurodevelopmental changes in babies’ brains, such as
New research by the University of
Virginia School of Medicine suggests.
A group of UVA experts
Neuroscientists discovered that antidepressants are commonly prescribed.
SSRIs are also known as selective serotonin reuptake inhibitors (SSRIs).
interact powerfully with inflammation in the mother’s body
This can be caused by infections or from other sources. This was tested in lab mice.
The interaction led to harmful changes in both the placenta (and the surrounding tissues)
decidua – the direct connection between mother and child
– and affected the developing brain.
“Our findings
It is possible to suggest that [SSRIs] These can have devastating consequences.
mixed with infection, inflammation, etc.,” said senior
John Lukens (Doctor of Philosophy, UVA Department of)
Neuroscience and its Center for Brain Immunology and Glia
(BIG) and the UVA Brain Institute. “Our results
Could explain why autism prevalence has risen over the years.
Last 20 years, because this time coincides avec the rollout
Widespread SSRI usage in developing countries
world.”
SSRIs During Pregnancy
SSRIs can be used to help you.
Commonly used during pregnancy, it is prescribed for up to 80%
Pregnant women may need to take depression medication. These drugs can be used for depression.
A safe way to manage depression is widely recognized.
Pregnant women have been shown to be more likely to get sick than they were before.
They can also increase the likelihood of premature births
This increases the chance of developing neurological issues or other health problems
problems in children.
Lukens and his associates
found that SSRIs can interact with the mother’s immune
system can produce strong inflammatory reactions at the
“maternal-fetal interface,” the physical connection
During pregnancy, mother and child.
The
Mothers who were later exposed to inflammation later had their offspring
Sexual-based behavior changes such as those seen in
Autism can cause communication difficulties in people with autism.
This led to a decrease in interest in social interactions. Such mouse models
These are an important part of autism research and are often used in a variety of ways.
tool.
“We identified inflammatory signatures in the
The correlation between placenta and neurologic changes in the
Mothers with an immune condition have their offspring as adults.
challenge during pregnancy,” said researcher Kristine
Zengeler, first author of a scientific paper
Outlining the findings. “These signatures could be used to
To help identify biomarkers, druggable targets and other potential help
Prenatal interventions can reduce neurodevelopmental effects
Environment stressors such as an immune system
response.”
Previous research has shown that infections can be prevented.
Autoimmune diseases and other conditions can alter the body’s ability to fight off illness
mother’s immune state during pregnancy can affect
neurodevelopment. The UVA researchers believe that SSRIs could be a way to help neurodevelopment.
It interacts with the inflammation and amplifies it.
This can lead to permanent brain changes.
These are the results
Researchers claim that SSRIs are responsible for the observed changes in behavior.
Serotonin levels in the body The body produces serotonin, which is a key mood regulator
regulator – it’s often thought of as a “feel good”
chemical in the brain — but it’s also a vital regulator
of the body’s immune response. Infants in development receive
serotonin comes only from their mothers via their placentas in the
Serotonin levels are disrupted in the early stages of pregnancy
Baby may also suffer from the consequences of mom’s actions.
The
Researchers found that inflammation can be used alone or in combination.
SSRIs can alter the serotonin levels within the placenta. However, they are not effective in reducing it.
opposite directions. “We found that mothers who
An immune challenge in pregnancy led to a
There was a totally different sign in the placenta between them when they were
on SSRIs compared to mothers that were not on SSRIs,”
Zengeler said. “This highlights the importance of
Consider the whole prenatal environment.
Inflammation may be reduced, which could lead to unexpected results
If they are combined with another, the consequences for the baby
modulators, such as SSRIs.”
The researchers made these observations
SSRIs can be a valuable tool for managing depression.
It was stressed that pregnant women shouldn’t stop taking them
They did not consult their doctors. Instead, scientists
Are calling for more studies in order to eventually be human.
Subjects to test the effects of drugs on mother and child.
To better understand the interactions between SSRIs, and children
inflammation.
“Untreated maternal stress, depression
Anxiety, panic, and fear can all be enough to cause distress in your family.
Neurodevelopment can lead to negative behavioral and
cognitive outcomes,” the researchers write. “It will
It is therefore important to take into consideration both the
SSRIs have potential side effects and relative benefits.
therapeutic option during pregnancy.”
Find out more
Published
Researchers published
Their findings were published in Brain, Behavior and Other Scientific Journals.
Immunity. Zengeler, Daniel A. and Daniel B. comprised the team.
Shapiro. Katherine R. Bruch. Catherine R. Lammert. Hannah
Ennerfelt & Lukens. Researchers reported that they had no financial concerns.
These are the interests that drive the work.
Lukens’ lab also recently
Made a discovery that might hold
the key for boosting the brain’s ability to fight
Alzheimer’s disease and multiple sclerosis.
The
lab’s latest research was supported by the National
Institutes of Health’s National Institute of Neurological
Disorders and Stroke grant R01NS106383. The National
Institute of Mental Health, grant R21MH120412-01 ;The Simons
Foundation Autism Research Initiative pilot award 515305
The Owens Family Foundation. Additionally, members of the
Cell and Molecular Biology supported the research team
Training Grants 1T32GM139787-01–35 and T32GM008136. Wagner
Fellowships, Double Hoo Awards, and a Harrison
Fellowship.
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